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Schematic diagram of Mnk 1/2 signaling. The extracellular signal‐regulated kinase and p38 mitogen‐activated protein kinase pathways phosphorylate and activate Mnk 1/2 kinases. Mnk 1/2 kinases phosphorylate the eukaryotic translation initiation factor 4E, which initiates protein translation and promotes tumor development. Mnk 1/2 kinases affect other less explored targets. The PI3K/Akt/mTOR/S6Ks pathway may also phosphorylate the eIF4E. P, phosphorylate.
