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. Author manuscript; available in PMC: 2020 Apr 15.
Published in final edited form as: J Affect Disord. 2019 Feb 19;249:347–356. doi: 10.1016/j.jad.2019.02.051

Figure 1.

Figure 1.

Experimental timeline. Adolescent (postnatal day [PD] 35) male and female C57BL/6 mice received fluoxetine (FLX; 20 mg/kg; IP) or water/control (VEH) for 15 consecutive days. Twenty-one days later (PD70+), separate groups of male and female mice were evaluated on memory performance on the (A) object recognition (B) or Morris water maze tests. (C) To evaluate whether the observed FLX-induced alterations on the Morris water maze in male mice were the result of age of FLX exposure, we conducted a similar experiment where adult male mice were exposed to FLX for 15 days (PD70–84). Three weeks post FLX exposure (PD105) mice were evaluated on the MWM task.