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. Author manuscript; available in PMC: 2020 Apr 15.
Published in final edited form as: J Affect Disord. 2019 Feb 19;249:347–356. doi: 10.1016/j.jad.2019.02.051

Figure 3.

Figure 3.

Fluoxetine (FLX; 20 mg/kg) exposure during adolescence did not influence acquisition performance during the spatial training phase (8 trials) of the Morris water maze task (PD70+; n= 10–11/group). Latency (A) and swim velocity (B) decreased across the training trials, indicating that mice acquired the memory task, independent of FLX history. On test day (24 hr post spatial training), no differences between the FLX and VEH pretreated mice were noted in latency to locate the escape platform (C) or swim velocity (D). Twenty-four hr later, during the probe trial (PD72), FLX pretreated animals took longer to reach the quadrant that had previously contained the escape platform (E) and spent significantly less time in it (F). Data are presented as mean + SEM. *Indicates p<0.05 when compared to VEH; β indicates p=.057 when compared to VEH.