Figure 5.

Fluoxetine (FLX; 20 mg/kg) exposure in adult male mice (PD70–84) does not influence spatial memory performance later in life (PD103–105). Latency (A) and swim velocity (B) decreased across the training trials, indicating acquisition of the memory task. No differences on latency to locate the escape platform (C) or swim velocity (D) were noted between the groups during the test day (PD106). Twenty-four hr later (PD107), during a standard probe trial, no differences in latency to reach the area that previously contained the escape platform (E) were noted between the groups. Similarly, no differences in the time spent in that quadrant that previously contained the platform (F) were apparent. Data are presented as mean + SEM.