Table 1.
List of candidate genes underlying proper eye development and function in mice. Only genes without a previously reported gene deletion phenotype in any of the 47 selected tissues in mice are included in this list.
| MGI Gene symbola | Number of ortholog(s)b |
Characterized vision/eye-related phenotypes due to mutations (or reduced expression, if noted) [gene symbol, speciesc], if available | |
|---|---|---|---|
| Human | Zebrafish | ||
| High confidence genes | |||
| Ankrd33d,e | 1 | 2 | Unreported |
| Arr3e | 1 | 2 | Knockdown caused a sever delay in photoresponse recovery [arr3, zebrafish] [34] |
| Cnga1e | 1 | 2 | Retinitis pigmentosa 49, RP49 [CNGA1, human] [35], [36] |
| Cryba4e | 1 | 1 | Cataracts and microphthalmia, CTRCT23 [CRYBA4, human] [37], [38] |
| Crybb3e | 1 | 1 | Congenital cataracts, CTRCT22 [CRYBB3, human] [39] |
| Gm4792e | 0 | 0 | Unreported |
| Gm9918e | 1 | 0 | Unreported |
| Grifind,e | 1 | 1 | Unreported |
| Kcnj14d,e | 1 | 1 | Unreported |
| Kcnv2e | 1 | 2 | Retinal cone dystrophy 3B, RCD3B [KCNV2, human] [40] |
| Lrit1e | 1 | 2 | Unreported until 2018; visual acuity impairments in optokinetic response [Lrit1, mouse] [32] |
| Lrit2d,e | 1 | 1 | Unreported |
| Mlanae | 1 | 0 | None [ps. no eye abnormality detected in mice [41]] |
| Pde6he | 1 | 1 | Incomplete achromatopsia [43] and Retinal cone dystrophy 3A, RCD3A [42] [PDE6H, human] |
| Ppef2d,e | 1 | 2 | Unreported |
| Ppm1nd,e | 1 | 2 | Unreported |
| Samd7e | 1 | 1 | Unreported until 2017; ectopic expression of nonrod genes and rod photoreceptor cell dysfunction [Samd7, mouse] [33] |
| Slc1a7e | 1 | 2 | Early pathological change in the development of aged-related macular degeneration [EAAT5, human] [44] |
| Stx3e | 1 | 2 | Congenital cataract and intellectual disability [STX3, human] [45] |
| Tmem215e | 1 | 0 | Unreported |
| Tspan10e | 1 | 1 | Unreported until 2019, concomitant strabismus [TSPAN10, human] [46] |
| Medium confidence genes | |||
| 4632404H12Rike | 0 | 0 | Unreported |
| Adald,e | 1 | 1 | Unreported |
| Car14d,e | 1 | 1 | Unreported |
| Ccdc126d,e | 1 | 1 | Unreported |
| Crxose | 0 | 0 | Unreported |
| Crybb1e | 1 | 1 | Pediatric or age-related cataracts CATARACT 17 [CRYBB1, human] [47], [48] |
| Crygne | 1 | 2 | Unreported |
| Defb9e | 0 | 0 | Unreported |
| Dhx32d,e | 1 | 2 | Unreported |
| Dkk3d,e | 1 | 2 | Unreported |
| Fabp12e | 1 | 3 | Unreported |
| Fam169ad | 1 | 2 | Unreported |
| Fam19a3e | 1 | 0 | Unreported |
| Frmpd2d,e | 1 | 1 | Unreported |
| Gzmme | 1 | 0 | Unreported |
| Impg1e | 1 | 2 | Vitelliform macular dystrophies [IMPG1, human] [49] |
| Lyg2e | 1 | 3 | Unreported |
| Make | 1 | 1 | Retinitis pigmentosa 62, RP62 [MAK, human] [50], [51] |
| Mgarpe | 1 | 0 | Unreported |
| Otore | 1 | 0 | Unreported |
| Pdzph1e | 0 | 1 | Unreported |
| Plk5 | 1 | 0 | Unreported |
| Pou6f2 | 1 | 1 | Knockdown suppressed retina regeneration [pou6f2, zebrafish] [52] |
| Rrhe | 1 | 1 | Retinitis punctata albescens [RRH, human] [53] |
| Slco4a1 | 1 | 1 | Expression reduction marks the occurrence of retinal detachment [SLCO4A1, human] [54] |
| Tldc1d,e | 1 | 1 | Unreported |
| Vite | 1 | 1 | Evolutionarily reduced expression linked to weakened vision during domestication [vit, chicken] [55] |
| Wdr174 | 1 | 1 | Unreported |
| Zfp563e | 1 | 0 | Unreported |
a
See Tables S11 and S12 for the corresponding MGI ID and full gene name.
b
See Table S15 for the corresponding gene IDs of the orthologs.
c
Human: Homo sapiens; mouse: M. musculus; chicken: Gallus gallus; zebrafish: Danio rerio.
d
Indicates genes which were functionally validated in zebrafish in the present study.
e
Eye candidate genes with a medium or a high confidence score when coexpressed gene modules were defined by PGCNA.