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. 2019 Sep 3;28(1):313–327. doi: 10.1016/j.ymthe.2019.08.015

Figure 2.

Figure 2

miR-5188 Promotes Breast Cancer Stemness, Metastasis, Proliferation, and Chemoresistance

(A) Mammosphere formation analysis during three serial passages (scale bars, 40 μm), (B and C) flow cytometry, (D) immunofluorescence analyses (scale bars, 10 μm), (E) wound-healing assays, (F) transwell assays (scale bars, 100 μm), (G) colony-formation assays, and (H) EdU incorporation assays (scale bars, 100 μm) of miR-5188-overexpressed MCF-7 and MDA-MB-468 cells and their control cells. (I) Drug sensitivity tests of MCF-7 and MDA-MB-468 cells treated with paclitaxel and epirubicin in a dose-dependent and time-dependent manner. *p < 0.05; **p < 0.01; ***p < 0.001.