Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Oct 25;13(1):137–146. doi: 10.1111/cts.12694

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

PMC Copyright notice

Identification of key metabolites associated with cellular response to methotrexate (MTX) by univariate and multivariate analysis of 724 identified metabolites. Metabolomics data were analyzed using MetaboAnalyst 3.0 and the resulting (a) principle component analysis scores plot, (b) volcano plot, (c) partial least squares discriminant analysis scores plot, and (d) variable importance in projection (VIP) score plot are presented. In the volcano plot, red‐colored metabolites represent those metabolites found to be increased in the MTX treated group, whereas the blue‐colored metabolites represent those metabolites that were found to be decreased and statistically significant metabolites (false discovery rate adjusted P value < 0.05) with a > 10‐fold change are labeled on the volcano plot. The top discriminating metabolites are presented in the VIP score plot and are the same metabolites identified in the volcano plot. FC, fold change; IMP, inosine monophosphate; PI, phosphatidylinositol.