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. 2019 Oct 25;13(1):147–156. doi: 10.1111/cts.12695

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© 2019 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Association among CYP2D6 metabolite formation rate and CYP2D6 messenger RNA (mRNA) and protein content. CYP2D6 metabolite formation rate was correlated with CYP2D6 mRNA content quantitated by RNA‐seq: dextrorphan formation rate (a) and alpha‐hydroxymetoprolol formation rate (b); with CYP2D6 protein content quantitated by liquid‐chromatography tandem mass spectrometry: dextrorphan formation rate (c) and alpha‐hydroxymetoprolol formation rate (d). FPKM, fragments per kilobase of transcript per million mapped reads