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. 2019 Oct 25;13(1):147–156. doi: 10.1111/cts.12695

Figure 5.

Figure 5

Functional characterization of rare CYP2D6 coding variants with CYP2D6 probe tic‐ABP1P. Each CYP2D6 variant was induced in an isogenic yeast strain and function was characterized with a tic‐ABP1P CYP2D6 probe. Fluorescence was normalized to that of CYP2D6 wildtype (medium grey; horizontal dashed line represents 100% activity). Control strains (light grey): empty vector, inactive variant (C443H), and decreased function variant (P34S). Rare coding variant strains (dark gray): P8S, S168A, D198N, P267L, V338M, A449D, and R474Q. Error bars indicate SEs from at least two independent replicates.