Table 1.
Comparison of systems used for CYP2D6 genotype to phenotype translation
| CPIC | DPWG | System 1a (n = 1) | System 2 (n = 1) | System 3 (n = 3) | System 4 (n = 1) | |
|---|---|---|---|---|---|---|
| AS | ||||||
| UM | > 2 | > 2.5 | ≥ 3 | ≥ 3 | > 2 | Not tested |
| NM to UM | 2.25 < x < 3 | 2.5 | ||||
| NM | 1−2 | 1.5−2.5 | 1.75 ≤ x ≤ 2.25 | 2 | 1.5−2 | 1b to 2 |
| IM to NM | 1.25 < x < 1.75 | 1.5 | ||||
| IM | 0.5 | 0.5−1 | 0.75 ≤ x ≤ 1.25 | 1 | 0.5−1 | 0.5−1b |
| PM to IM | 0 < x < 0.75 | 0.5 | ||||
| PM | 0 | 0 | 0 | 0 | 0 | 0 |
AS, activity score; CPIC, Clinical Pharmacogenetics Implementation Consortium; DPWG, Dutch Pharmacogenomics Working Group; IM, intermediate metabolizer; NM, normal metabolizer; PM, poor metabolizer; UM, ultrarapid metabolizer.
AS ranges shown in gray are not reported. n refers to the number of laboratories that reported using the system.
aThis laboratory utilizes a propriety system of values to determine AS. bNM AS = 1 is a combination of a fully functional allele plus a no function allele; IM AS = 1 is a combination of two decreased function alleles.