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Schematic representations of quasi‐steady state (QSS) model (a), Michaelis−Menten‐binding kinetic(MM‐BK) model (b) and indirect response (IDR) models (c). kdeg, first order degradation; kel, first order elimination; kint, first order internalization; km, kinetic metabolite; kss, steady state constant; ksyn, zero‐order synthesis; Vmax, maximal rate of metabolism.
