Skip to main content
. 2019 Sep 3;28(1):189–201. doi: 10.1016/j.ymthe.2019.08.016

Figure 5.

Figure 5

KPT-350 Treatment Results in Decreased Inflammatory Cytokine Expression in D2-mdx Mice

(A–I) WT and D2-mdx mice were given oral KPT-350 three times a week for 8 weeks. Terminal blood serum was collected and assayed for pro-inflammatory cytokines, which are upregulated in D2-mdx mice. KPT-350 treatment significantly reduced various pro-inflammatory and apoptosis-related cytokines. In addition, KPT-350 treatment significantly increased the expression of anti-inflammatory cytokines that are reduced in vehicle-treated D2-mdx mice (J and K). Mean ± SEM. n = 5. ***p < 0.001, ****p < 0.0001, two-way ANOVA with a Tukey correction.