TABLE 3.
Repeatability of Lesion 18F-NaF PET SUV Metrics
| Metric | RC | ICC* | CV (%) | CPD (%) | B† |
| UWCCC (265 lesions) | |||||
| SUVmax | 0.23 | 0.980 (0.974, 0.984) | 11.7 | 37.5 | 1.00 (0.79, 1.25) |
| SUVmean | 0.10 | 0.983 (0.979, 0.987) | 5.5 | 15.9 | 1.00 (0.90, 1.11) |
| SUVtotal | 0.40 | 0.990 (0.987, 0.992) | 20.7 | 75.9 | 1.04 (0.69, 1.56) |
| MSKCC (78 lesions) | |||||
| SUVmax | 0.31 | 0.958 (0.935, 0.973) | 16.8 | 54.3 | 1.04 (0.75, 1.45) |
| SUVmean | 0.14 | 0.970 (0.953, 0.981) | 7.8 | 22.2 | 1.03 (0.88, 1.19) |
| SUVtotal | 0.60 | 0.990 (0.985, 0.994) | 32.7 | 133.6 | 1.08 (0.57, 2.06) |
| NCI (68 lesions) | |||||
| SUVmax | 0.37 | 0.865 (0.791, 0.915) | 20.6 | 69.2 | 0.97 (0.65, 1.46) |
| SUVmean | 0.16 | 0.876 (0.807, 0.922) | 9.2 | 26.2 | 0.98 (0.82, 1.17) |
| SUVtotal | 0.65 | 0.993 (0.989, 0.996) | 36.6 | 151.4 | 1.00 (0.49, 2.06) |
| All sites (411 lesions) | |||||
| SUVmax | 0.27 | 0.969 (0.963, 0.975) | 14.1 | 47.2 | 1.00 (0.76, 1.32) |
| SUVmean | 0.13 | 0.975 (0.970, 0.980) | 6.6 | 19.6 | 1.00 (0.88, 1.14) |
| SUVtotal | 0.49 | 0.990 (0.988, 0.992) | 25.5 | 100.4 | 1.04 (0.63, 1.71) |
*
Data in parentheses are 95% confidence intervals.
†
Data in parentheses are 95% LOA.
RC = repeatability coefficient for α = 0.05 (log-transformed SUV); CV = log-transformed coefficient of variation; CPD = critical percentage difference; B = ratio of test-to-retest bias.
B and 95% LOA have been back-transformed to original units.