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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Biochem Pharmacol. 2019 Nov 21;171:113727. doi: 10.1016/j.bcp.2019.113727

Figure 4.

Figure 4.

Effect of G-1 on ISO-induced Ca2+ signals in cardiomyocytes. A, Intracellular Ca2+ time courses in response to 1 μM ISO in PMCMs pretreated for 15 min with the specified concentrations of metoprolol (METO) or ICI-118551 (ICI) before ISO addition (arrow). B–C, Intracellular Ca2+ (B) and corresponding integrated AUC (C) time courses in response to 1 μM ISO in PMCMs pretreated for 15 min with the specified concentrations of GPER agonist G-1 before ISO addition (arrows). D, Average integrated AUC values. ****, p <0.0001; n = 12 – 22 cells from 9 – 16 experiments for each condition.