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. 2020 Jan 9;15(1):e0225392. doi: 10.1371/journal.pone.0225392

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© 2020 Shang et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 5 — (A) PCA analysis of RNA-Seq transcriptome on top 500 variance genes across all Groups. (B) Differentially Expressed Genes and GSEA enriched pathways between different sex and APOE genotypes. (C-E) Average heatmap of each sex and APOE genotype groups of genes directly involved in glycolysis, β-oxidation, and TCA cycle. (F) Average heatmap of mitochondrial encoded genes in each group showed lower mt-genes in APOE4 carriers comparing to their APOE3 compartments. Overall, males exhibited a transcriptome characterized by greater glycolytic and corresponding TCA transcriptome which was augmented in APOE4 males. In contrast, females exhibited a transcriptome characterized by expression of genes required for beta oxidation of lipids with a concomitant rise in subunits required for electron transport chain complex II.