Figure 1.

Formulation and Characterization of ECO/pCMV-ABCA4 Nanoparticles with Lipofectamine as Control

(A–F) ECO structure (A), agarose gel electrophoresis (B), and transmission electron microscopy (C), DLS measurements of nanoparticle size (D), size distribution (E), zeta potential (F), and ABCA4 mRNA expression levels in ARPE-19 cells (G) of the nanoparticles. (DLS measurements were performed at particle counts from 150∼400 kcounts/s. Relative frequency intensity weighted nanoparticle size distribution and zeta potential were recorded. Scale bar represents 100 nm. Statistical analysis was conducted with two-tailed Student’s t test. **p < 0.05.)