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Efficacy of ECO/pRHO-ABCA4 for Preventing A2E Accumulation in Abca4−/− Mice
(A and B) HPLC chromatograms (A) and relative quantity (B) of A2E extracted from the eyes of Abca4−/− mice treated with ECO/pRHO-ABCA4 and ECO/pCMV-ABCA4 with PBS as a control. (C) H&E staining of the retina after the treatments. (n = 8, error bars ± SD, **p < 0.05 relative to contralateral control eyes. Statistical analysis was conducted with two-tailed Student’s t test.)
