TABLE 3.

Cointegrate formation frequencies

IS type and IS	Target	Cointegration frequencya
		Range	Mean (SD)
Untargeted replicative
IS257-3	R388	<4.32 × 10–8 to <9.45 × 10–8	<7.47 × 10–8
IS257R2	R388	<5.55 × 10–8 to <8.99 × 10–8	<7.84 × 10–8
IS1216	R388	9.00 × 10–8 to 4.14 × 10–7	4.47 × 10–7 (3.74 × 10–7)
IS26	R388	2.1 × 10–7 to 7.03 × 10–7	5.14 × 10–7 (2.66 × 10–7)
Targeted conservative
IS257-3	R388::IS257-3	3.10 × 10–6 to 6.67 × 10–6	5.11 × 10–6 (1.82 × 10–6)
IS257R2	R388::IS257R2	2.30 × 10–6 to 5.91 × 10–6	3.59 × 10–6 (2.02 × 10–6)
IS1216	R388::IS1216	4.33 × 10–5 to 9.38 × 10–5	6.99 × 10–5 (2.53 × 10–5)
IS26	R388::IS26	3.29 × 10–4 to 6.09 × 10–4	4.88 × 10–4 (1.44 × 10–4)

^aFrequency was measured as the number of cointegrates per transconjugant. The number of replicates was 3 in every case.