TABLE 1.
Functional distribution of PUUP-responding genesa
| GO term | PUUP data set frequency (%) | Genome frequency (%) | P value | Genes annotated to the GO term |
|---|---|---|---|---|
| Upregulated genes | ||||
| Response to chemicals | 28 | 8.88 | 2.22E−08 | ECM4, FES1, FRM2, HAP4, HBN1, HSP104, HSP12, HSP31, IML2, MIG2, NQM1, NRG1, PDR15, PDR16, PDR3, PDR5, RPN4, SIS1, SNQ2, SSA1, SSA4, TDA1, TPO1, XBP1, YJL144W, YKL071W, YNL134C, YOR1 |
| Transmembrane transport | 12 | 7.32 | 3.09E−02 | BAP2, HXT5, MPC3, PDR15, PDR5, PMC1, PUG1, SNQ2, SSA1, SSA4, TPO1, YOR1 |
| Protein folding | 10 | 1.75 | 9.52E−06 | APJ1, BTN2, CUR1, HSP104, HSP26, HSP78, HSP82, SIS1, SSA1, SSA4 |
| Response to heat | 8 | 1.4 | 7.51E−05 | CUR1, HSP104, HSP12, HSP26, HSP78, HSP82, SSA1, SSA4 |
| Response to oxidative stress | 8 | 1.91 | 5.59E−04 | FRM2, HBN1, HSP104, HSP12, HSP31, NQM1, TDA1, XBP1 |
| Downregulated genes | ||||
| Conjugation | 25.71 | 1.91 | 9.74E−16 | AFB1, AGA1, FAR1, FIG1, FIG2, FUS1, FUS2, FUS3, GPA1, KAR4, MF(ALPHA)1, MF(ALPHA)2, PRM1, PRM3, SAG1, SST2, STE2, STE3 |
| Response to chemical | 20 | 8.88 | 2.01E−03 | AFB1, AGA1, FAR1, FIG2, FUS3, GPA1, KAR4, MF(ALPHA)1, MF(ALPHA)2, SAG1, SAM3, SST2, STE2, STE3 |
| Transposition | 12.86 | 1.77 | 3.73E−06 | FUS3, TEC1, YAR010C, YBL005W-A, YDR365W-B, YJR027W, YOL103W-B, YPR137C-A, YPR158C-D |
| Transmembrane transport | 12.86 | 7.32 | 3.80E−02 | FTR1, HXT4, HXT7, POR1, PRM6, SAM3, YCT1, ZRT1, ZRT2 |
| Signaling | 11.43 | 5.62 | 2.60E−02 | FUS2, FUS3, GPA1, MF(ALPHA)1, MF(ALPHA)2, SST2, STE2, STE3 |
| DNA recombination | 8.57 | 3.93 | 3.71E−02 | NDJ1, SHU1, YDR365W-B, YJR027W, YOL103W-B, YPR158C-D |
a
Data (100 upregulated genes and 73 downregulated genes) were organized into Gene Ontology (GO)-based biological process categories using the GO Term Mapper tool (https://go.princeton.edu/cgi-bin/GOTermMapper). Significantly overrepresented categories (P ≤ 0.05) with a PUUP data set frequency of ≥8% are listed.