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. 2020 Jan 8;5(1):e00918-19. doi: 10.1128/mSphere.00918-19

TABLE 2.

Calculated fractional occupancy of β-lactamases at various concentrations of BLIPK74T/W112D

β-Lactamase Fractional occupancy (f) vs concn of BLIP mutanta :
10 nM 50 nM 200 nM 1,000 nM 2,850 nM
KPC-2 0.806 0.952 0.988 0.998 0.999
CTX-M-14 0.011 0.052 0.182 0.524 0.758
CTX-M-15 0.023 0.103 0.313 0.699 0.870
TEM-1 0.002 0.008 0.031 0.139 0.313
a

Fractional occupancy (f) is the fraction of β-lactamase bound at each listed concentration of the BLIPK74T/W112D mutant. The equation for determining f is provided in Materials and Methods.