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. 2020 Jan 7;26(1):21–34. doi: 10.3748/wjg.v26.i1.21

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Overexpression of phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 could promote the metastasis of gastric cancer cells. A: SGC-7901 cells were subjected to wound healing assay, and the cells were treated with phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 overexpressing lentivirus and vector control lentivirus particles for 24 h; B: The relative migration index was calculated by the width of the wound scratch of panel A; C: Transwell assay was used to examine the effect of phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 in the invasion of SGC-7901 cells; D: The relative invasion index was calculated by the number of invasive cells in three different fields. ^eP < 0.001 vs pCDH. PREX1: Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1.