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. 2020 Jan 7;26(1):86–96. doi: 10.3748/wjg.v26.i1.86

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Survival analysis of subgroups of patients depending on serum microRNA-122 level. A: Survival analysis in relation to serum miR-122 in all patients [divided into two groups: < 25^th percentile (n = 22), ≥ 25^th percentile (n = 69)]; B: Survival analysis in relation to serum miR-122 in patients with Child-Pugh class B or C [divided into two groups: < 25^th percentile (n = 7), ≥ 25% percentile (n = 23)]; C: Survival analysis in relation to serum miR-122 in patients with Barcelona clinic liver cancer stage B/C/D [divided into two groups: < 25^th percentile (n = 18), ≥ 25^th percentile (n = 57)]; D: Survival analysis in relation to serum miR-122 in patients with normal alpha-fetoprotein (AFP) (AFP < 7 ng/mL) [divided into two groups: < 25^th percentile (n = 8), ≥ 25^th percentile (n = 25)]. Nonparametric log-rank test was used for statistical analysis. P < 0.05 miR-122 < 25^th percentile vs miR-122 ≥ 25^th percentile. BCLC: Barcelona clinic liver cancer; AFP: Alpha-fetoprotein.