Table 3.

P‐values as results of TFAS separating tracts with significant differences between Shank3‐isoform–specific heterozygous KO and wt at 4 weeks and at 9 weeks.

	FT I	FT II	FT III	FT IV	FT V	Whole brain
wt (4 weeks) versus wt (9 weeks)	0.63	0.06	0.14	0.53	0.71	0.94
Shank3 versus wt (4 weeks)	0.52	0.21	0.002	0.002	0.70	0.004
Shank3 versus wt (9 weeks)	0.84	0.94	0.66	0.82	0.23	0.99
Shank3 (4 weeks) versus Shank3 (9 weeks)	0.48	0.17	0.04	0.05	0.30	0.02

Significance is marked in yellow with P < 0.05. FT I: part of CC connection to frontal association cortices; FT II: anterior commissure; FT III: association fiber tract from motor cortex to entorhinal cortex; FT IV: fronto‐occipital association fiber tract connecting V1 and frontal association cortex; FT V: corticostriatal pathway. CC, corpus callosum; FT, fiber tract; Shank3, SH3 and multiple ankyrin repeat domains 3. TFAS, tractwise fractional anisotropy statistics; wt, wildtype.