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. 2020 Jan 9;10:96. doi: 10.1038/s41598-019-56146-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Clinical and immunochistochemical (IHC) validation of the transcriptional signature. (a) Selection of all patients with recurrent ganglioglioma (GG-Group 2, n = 11) from the local LEAT database. Ten patients without recurrence but matched by age, sex and tumor localization were used as a control group (GG-Group 1). (b) MRI example of a patient with malignant ganglioglioma. (c) IHC analysis of CD34, BRAF-V600 mutation status, PTEN, p-S6K and p-MAPK in both GG-Group 1 and GG-Group 2. (d) The bar plots show a quantification of protein expression analysis of the CD34, p-S6K and p-MAPK signaling for both groups P-values are determined by one-way ANOVA adjusted by Benjamini-Hochberger for multiple testing. Data is given as mean ± standard deviation. (e) Presentation of oncological data (progression and survival) together with BRAF-V600E and PTEN mutation status for both groups (f) Kaplan-Meier-curves comparing the PFS between both groups after stratification for BRAF-V600E.