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. 2020 Jan 9;3:18. doi: 10.1038/s42003-019-0743-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The K_D of wild-type ABL is normalized. Most clinically resistant mutants (red) have higher K_D values. The non-clinical resistance mutation (blue) K_D is generally between wild-type (black) and clinically resistant mutants, but there are exceptions, such as the F382Y mutation in imatinib's prediction. a–e The normalized K_D values of imatinib, nilotinib, dasatinib, bosutinib and ponatinib, respectively. (K_D values for WT are all set to be 1). n = 3 biologically independent experiments.