Fig. 6. Half-maximal inhibitory concentrations and enzyme kinetic constants of ABL mutants and drugs.

All data are normalized to the catalytic efficacy of wt ABL and the corresponding half-maximal inhibitory drug concentrations (red star). The drugs generally have high IC₅₀ values against the p-c mutants (orange), while the IC₅₀ values against the p-nc mutants (blue) are similar to the wt enzymes.