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The balance of PI3K/Akt signaling, the maintenance of JAK/STAT5 signaling, and their complex interplay in the survival of TRM cells. The activation of both PI3K/Akt signaling and JAK/STAT5 signaling support TRM cell survival (left). However, the constitutive activation of PI3K/Akt represses IL-7/IL-15 receptor expression and STAT5 phosphorylation (right)
