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. 2020 Jan 9;3:20. doi: 10.1038/s42003-019-0747-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Vascular canal volume per volume of interest (VOI), b mean vascular canal segment volume, c vascular density, d mean vascular canal segment length, and e mean vascular canal segment diameter. Vascular canal volume significantly decreased due to a significant reduction in canal diameter in the femoral cortices of STZ compared with euglycemic group at both 1 month and 3 months (linear regression for a, b, e; two-way ANOVA and post-hoc Newman–Keuls for c, d; mean ± SD, statistical significances (p < 0.05) between the groups are indicated by a–d, n = 6 animals).