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. 2020 Jan 2;11(1):4. doi: 10.1038/s41419-019-2198-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, b PI staining a and quantification b show that knockdown of Arc further increased neuronal necrosis after TNI. c Electron microscopy shows morphological changes of necroptosis in neurons after TNI and Si-Arc-3 transfection. d Western blot shows that knockdown of Arc further increased RIP1 expression after TNI. e Cell viability assay shows that Nec-1, but not Nec-1i, partially prevented the Si-Arc-3-induced decrease of cell viability after TNI. f LDH release assay shows that Nec-1, but not Nec-1i, partially prevented the Si-Arc-3-induced increase of LDH release after TNI. Error bars indicate SEM (n = 6). *p < 0.05 vs. control group. ^&p < 0.05 vs^. TNI + Si-control group. ^#p < 0.05 vs. TNI + Si^-Arc-3 group.