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. 2020 Jan 9;10:64. doi: 10.1038/s41598-019-56896-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CHS in felines is associated with a 20 kb tandem segmental duplication in LYST. (a) Samplot output showing increased coverage across LYST exons 30 through 38 with reverse orientation read pairs colored in red spanning the duplicated region. (b) Schematic of NM_001290242.1:c.8347-2422_9548 + 1749dup in normal and affected individuals. Introns are depicted as a thin blue line and exons are depicted as thick blue lines. Duplicated region is highlighted in red and is ~20 kb in length. Zoomed in region shows primer pairs overlapping duplication breakpoints. Note, primers Right_BP_F and Left_BP_R produce an amplicon in affected/carrier samples that was absent in normal samples.