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. 2020 Jan 9;10:83. doi: 10.1038/s41598-019-57053-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of calcineurin inhibitor FK506 on the S-SCAM overexpression-induced loss of GABA_A γ2 receptor clusters. (a) Representative images of GABA_AR γ2 in hippocampal neurons transfected with DsRed or myc-S-SCAM treated with either DMSO (Control) or FK506 (50 nM). (b) Quantification of the FK506 effect on GABA_AR γ2 clusters. n = 27 (DsRed Control), 26 (DsRed FK506), 25 (S-SCAM Control), 22 (S-SCAM FK506). Two-way ANOVA, interaction F_(1,96) = 6.217, p = 0.0144, treatment group F_(1,96) = 5.383, p = 0.0224, construct group F_(1,96) = 21.69, p < 0.0001, Tukey’s post-hoc test. (c) Effect of SCAM overexpression on the GABA_AR γ2 protein levels. Actin is used as a loading control. n = 3, Unpaired t test. F_(1,4) = 26.63, p = 0.072. Scale bars, 5 μm.