Figure 13.

Characteristics of resting Vm and APs in LMCs in the walls of pressurized IALs from WT and Ca_v3.1^−/−; Ca_v3.2^−/− double KO mice. (A,B) Representative recordings of Vm in the two strains. There was substantial cell to cell variation in the AP spike height, but these recordings are reasonably representative. (C–J) Summary of comparisons of resting Vm (C) and AP characteristics (D–J) as analyzed in the same manner described in ref. ⁵². There were no significant differences in any of the parameters between the two mouse strains, although there were trends for a few parameters (e.g. AP threshold, diastolic depolarization rate, upstroke exponential depolarization time constant) to be lower in Ca_v3.1^−/−; Ca_v3.2^−/− vessels.