TABLE 1.
Patient Characteristics by Surgery Year
| Overall (n = 449) | NSM before 2011 (n = 105) | NSM after 2011 (n = 344) | p-value | |
|---|---|---|---|---|
| Median Age, years (range) | 45 (24–75) | 44 (25–64) | 45 (24–75) | 0.51 |
| Family History | ||||
| Breast Cancer (≥ 1st Degree) | 118 (26.3%) | 27 (25.7%) | 90 (26.2%) | 0.90 |
| Ovarian Cancer (≥ 1st Degree) | 11 (2.4%) | 6 (5.7%) | 5 (1.5%) | 0.03a |
| Genetic Testing | 0.07 | |||
| No | 179 (39.9%) | 50 (47.6%) | 129 (37.5%) | |
| Yes | 270 (60.1%) | 55 (52.4%) | 215 (62.5%) | |
| Mutations Detected (n = 270) | ||||
| BRCA1 | 28 (10.4%) | 6 (10.9%) | 22 (10.2%) | 0.81 |
| BRCA2 | 18 (6.7%) | 5 (9.1%) | 13 (6.0%) | 0.38 |
| Smoking Status | 0.83 | |||
| Current Smoker | 25 (5.6%) | 6 (5.7%) | 19 (5.5%) | |
| Never Smoker | 326 (72.6%) | 74 (70.5%) | 252 (73.3%) | |
| Former Smoker | 98 (21.8%) | 25 (23.8%) | 73 (21.2%) | |
| Prior Radiation | 0.08 | |||
| Yes | 32 (7.1%) | 12 (11.4%) | 20 (5.8%) | |
| No | 417 (92.9%) | 93 (88.6%) | 324 (94.2%) | |
| Preoperative MRI | < .00 lb | |||
| Yes | 294 (65.5%) | 43 (41.0%) | 251 (73.0%) | |
| No | 155 (34.5%) | 62 (59.0%) | 93 (27.0%) | |
| Contralateral Prophylactic NSM | 0.63 | |||
| Yes | 310 (69.0%) | 75 (71.4%) | 235 (68.3%) | |
| No | 139 (31.0%) | 30 (28.6%) | 109 (31.7%) |
NSM nipple-sparing mastectomy
a
bold increased frequency of family history of ovarian cancer in cases before 2011
b
bold denotes increased use of preoperative MRI