. 2019 Dec 5;69(1):95–102. doi: 10.1007/s00262-019-02442-5

Table 1.

Shift models for the DLT probabilities in Cohort 1

Mel12.1 and poly +		Model 1 (shift = 0)		Model 2 (shift = 1)		Model 3 (shift = 2)
Mel12.1 and poly +		CD27 (−)	CD27 (+)	CD27 (−)	CD27 (+)	CD27 (−)	CD27 (+)
CD40 dose	50	$0 . 08^{exp (a_{1})}$	$0 . 08^{exp (a_{1})}$	$0 . 08^{exp (a_{2})}$	$0 . 15^{exp (a_{2})}$	$0 . 08^{exp (a_{3})}$	$0 . 24^{exp (a_{3})}$
	200	$0 . 15^{exp (a_{1})}$	$0 . 15^{exp (a_{1})}$	$0 . 15^{exp (a_{2})}$	$0 . 24^{exp (a_{2})}$	$0 . 15^{exp (a_{3})}$	$0 . 33^{\exp (a_{3})}$
	600	$0 . 24^{exp (a_{1})}$	$0 . 24^{exp (a_{1})}$	$0 . 24^{exp (a_{2})}$	$0 . 33^{\exp (a_{2})}$	$0 . 24^{exp (a_{3})}$	$0 . 43^{exp (a_{3})}$
	1200	$0 . 33^{\exp (a_{1})}$	$0 . 33^{\exp (a_{1})}$	$0 . 33^{\exp (a_{2})}$	$0 . 43^{exp (a_{2})}$	$0 . 33^{\exp (a_{3})}$	$0 . 53^{exp (a_{3})}$
		↓ Group A	↓ Group B	↓ Group A	↓ Group B	↓ Group A	↓ Group B

For each model, the highest acceptable arm in each group is denoted in bold