Skip to main content

View full-text article in PMC

. 2019 Dec 5;69(1):95–102. doi: 10.1007/s00262-019-02442-5

Table 2.

Shift models for the DLT probabilities in cohort 2

Mel12.1 +	Model 1 (shift = 0) IFA < PolyICLC		Model 2 (shift = 1) IFA < PolyICLC		Model 3 (shift = 2) IFA < PolyICLC
Mel12.1 +	CD27 (−)	CD27 (+)	CD27 (−)	CD27 (+)	CD27 (−)	CD27 (+)
IFA	$0 . 15^{exp (a_{1})}$	$0 . 15^{exp (a_{1})}$	$0 . 15^{exp (a_{2})}$	$0 . 24^{exp (a_{2})}$	$0 . 15^{exp (a_{3})}$	$0 . 33^{\exp (a_{3})}$
Poly	$0 . 24^{exp (a_{1})}$	$0 . 24^{exp (a_{1})}$	$0 . 24^{exp (a_{2})}$	$0 . 33^{\exp (a_{2})}$	$0 . 24^{exp (a_{3})}$	$0 . 43^{exp (a_{3})}$
Poly + IFA	$0 . 33^{\exp (a_{1})}$	$0 . 33^{\exp (a_{1})}$	$0 . 33^{\exp (a_{2})}$	$0 . 43^{exp (a_{2})}$	$0 . 33^{\exp (a_{3})}$	$0 . 53^{exp (a_{3})}$
	↓ Group C	↓ Group D	↓ Group C	↓ Group D	↓ Group C	↓ Group D

Mel12.1 +	Model 4 (shift = 0) IFA > PolyICLC		Model 5 (shift = 1) IFA > PolyICLC		Model 6 (shift = 2) IFA > PolyICLC
	CD27 (−)	CD27 (+)	CD27 (−)	CD27 (+)	CD27 (−)	CD27 (+)
IFA	$0 . 24^{exp (a_{4})}$	$0 . 24^{exp (a_{4})}$	$0 . 24^{exp (a_{5})}$	$0 . 43^{exp (a_{5})}$	$0 . 24^{exp (a_{6})}$	$0 . 33^{\exp (a_{6})}$
Poly	$0 . 15^{exp (a_{4})}$	$0 . 15^{exp (a_{4})}$	$0 . 15^{exp (a_{5})}$	$0 . 33^{\exp (a_{5})}$	$0 . 15^{exp (a_{6})}$	$0 . 43^{exp (a_{6})}$
Poly + IFA	$0 . 33^{\exp (a_{4})}$	$0 . 33^{\exp (a_{4})}$	$0 . 33^{\exp (a_{5})}$	$0 . 53^{exp (a_{5})}$	$0 . 33^{\exp (a_{6})}$	$0 . 53^{exp (a_{6})}$
	↓ Group C	↓ Group D	↓ Group C	↓ Group D	↓ Group C	↓ Group D

For each model, the highest acceptable arm in each group is denoted in bold