Table 1.
Physiological information, calculations used to create the lung device. Physiological human male organ volumes and flow rates from the literature (Haber et al., 2003; Price et al., 2000) were scaled down to create our device’s organ volumes and residence times. Residence time = organ volume/flow rate. The channel dimensions were estimated by using the Hagen–Poiseuille’s equation, the channel’s cross-sectional areas, volumetric flow rates (desired) and linear flow rates (desired) were calculated for the device held at a 5 degree angle.
| Organs | Organ volumes from literature (liters) |
Device organ volumes (μL) |
Flow rate from literature (L/min) |
Residence time (min) |
Channel X-sectional area (mm2) |
Calculated flow rate (Desired) (μL/s) |
Calculated linear flow rate (Desired) (mm/s) |
|---|---|---|---|---|---|---|---|
| Lung | 1.01 | 30.3 | 2.44 | 0.41 | 0.152 | 1.22 | 8.0 |
| Liver | 1.57 | 47.1 | 1.32 | 1.19 | 0.116 | 0.66 | 5.7 |
| Tumor | 0.10 | 3.0 | 0.06 | 1.67 | 0.028 | 0.03 | 1.1 |