Table 3.
Neurodevelopmental Functioning Measures by Microcephaly Status, among those with Both Head Circumference Measures and Neurodevelopmental Assessments
| Microcephaly (Nellhaus) |
Microcephaly (SMARTT) |
|||||||
|---|---|---|---|---|---|---|---|---|
| Neurodevelopmental Score | No |
Yes |
Difference |
No |
Yes |
Difference |
||
| Mean (SD) | Mean (SD) | Mean (SE) | P-Value | Mean (SD) | Mean (SD) | Mean (SE) | P-Value | |
| Bayley-III at age 1 year | ||||||||
| N=1405–1449 | N=97–99 | N=1462–1506 | N=40–41 | |||||
| Cognitive score | 103·1 (14·1) | 97·5 (17·4) | 5·58 (1·50) | 0·011 | 103·1 (14·1) | 90·9 (20·5) | 12·2 (2·26) | <·001 |
| Motor score | 97·5 (13·1) | 92·3 (16·3) | 5·17 (1·40) | 0·002 | 97·5 (13·0) | 84·6 (20·0) | 12·8 (2·11) | <·001 |
| Language score | 94·4 (14·1) | 90·8 (14·9) | 3·57 (1·50) | 0·043 | 94·4 (14·1) | 85·7 (16·9) | 8·67 (2·27) | 0·003 |
| General adaptive score | 94·6 (14·9) | 91·0 (17·4) | 3·59 (1·58) | 0·075 | 94·6 (14·8) | 85·8 (20·6) | 8·84 (2·40) | 0·002 |
| Social-emotional score | 101·5 (17·9) | 98·0 (16·7) | 3·47 (1·87) | 0·064 | 101·5 (17·9) | 94·0 (16·5) | 7·49 (2·86) | 0·029 |
| WPPSI-III at age 5 years | ||||||||
| N=1124–1141 | N=70–72 | N=1148–1188 | N=23–25 | |||||
| Full Scale IQ | 94·8 (14·9) | 89·8 (16·5) | 5·06 (1·84) | 0·006 | 94·7 (14·9) | 85·4 (15·7) | 9·36 (3·02) | 0·002 |
| Verbal IQ score | 92·5 (13·8) | 89·4 (15·0) | 3·05 (1·69) | 0·072 | 92·4 (13·8) | 87·3 (15·3) | 5·08 (2·80) | 0·070 |
| Performance IQ Score | 97·2 (15·4) | 92·3 (16·1) | 4·92 (1·88) | 0·009 | 97·1 (15·5) | 87·8 (15·7) | 9·31 (3·13) | 0·003 |
| Processing Speed Score | 95·8 (15·6) | 91·3 (16·1) | 4·53 (1·94) | 0·020 | 95·7 (15·6) | 86·5 (14·6) | 9·22 (3·29) | 0·005 |
P-value by Wilcoxon Test
SD=standard deviation, SE=standard error, WPPSI=Wechsler Preschool and Primary Scales of Intelligence