Figure 6.

Modulation of aggregation suppression ability of sHsp hetero-oligomers. The heat map shows negative modulation (indicating inhibition) in blue and positive modulation (indicating activation) in red. Modulation values equate to the difference of real activity and theoretical activity. Theoretical activity is defined as the sum of single sHsp control chaperone activities. Hence, normalized end-point aggregation values from Fig. 5 were subtracted to receive activity differences for indicated concentrations. For all experiments, the cutoff for color conditional formatting was set to 0.1, which equals the averaged standard deviation. Outlined boxes indicate physiological relevant ratios of the specific hetero-oligomers according to Table 1.