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. 2019 Dec;21(4):417–428. doi: 10.31887/DCNS.2019.21.4/kressler

Table I. Genome-wide association studies in PTSD. GTP- Grady Trauma Project; DCHS-Drakenstein Child Health Study; 
NHSII- Nurses’ Health Study II.

Study Sample Size Cohort SNP(s) Gene P value Highlights
Logue et al, 2013 Discovery: 
N=491 Discovery: white European American military veterans rs8042149 Retinoid-related orphan receptor alpha (RORA) 2.50E-08
Replication: N=600 Replication: African American military veterans
Xie et al, 
2013 Discovery: 
N=4344 European American and African American rs6812849 Tolloid-Like 1 (TLL 1) 3.10E-09
Replication: N=2643 European American and African American
Guffanti et al, 2013 Discovery: 
N=413 Discovery: DNHS women rs10170218 LINC01090 
(long noncoding RNA) 5.09E-08
Replication: N=2541 Replication: NHSII women
Wolf et al, 
2014 Discovery: 
N=484 European American military veterans rs263232 Adenylyl cyclase 8 (ADCY8) 6.12E-07
Nievergelt 
et al, 2015 Discovery: 
N=3494 MRS military 
veterans rs6482463 Phosphoribosyl transferase 
domain containing 1 (PRTFDC1) 2.04E-09
Replication: N=491
Almli et al, 
2015 Discovery: 
N=147 Discovery: Military veterans rs717947 BC036345 
(long noncoding RNA) 1.28E-08
Replication: N=2006 Replication: GTP Large urban 
community cohort
Ashley-Koch 
et al, 2015 Discovery: N=1708 Non-Hispanic black (NHB)
 Non-Hispanic white (NHW) rs7866350 (NHW Cohort) TBC1domain family member 2 (TBC1D2) 1.10E-06
Stein et al, 
2016 Discovery: N=7774 American military veterans rs159572 Ankyrin repeat domain 55 (ANKRD55) 2.34E-08
Replication: N=5916 rs11085374 Zinc finger prot. 626 (ZNF626) 4.59E-08
Kilaru et al, 2016 Discovery: 
N=3678 GTP Large urban 
community cohort N/A Neuroligin 1 (NLGN1) minSNP: 1.00E-06
Replication: N=205 DCHS pregnant south African women N/A ZNRD1-AS1 
(long noncoding RNA) VEGAS: 1.00E-06
Melroy-Greif 
et al, 2017 Discovery: 
N=512 Mexican Americans and American Indians rs6681483
rs6667389
rs10888255
 rs10888257 Olfactory receptor family 11 
subfamily L Member 1 (OR11L1) 1.83E-06
Duncan et al, 2017 Discovery: N=20730 Trauma exposed adults from 11 
contributing studies rs139558732 
African 
American Kelch-like protein 1 (KLHL1) 3.33E-08 PGC-PTSD
Morey et al, 2018 Discovery: N=157 European American and African American military veterans rs6906714
rs17012755
rs76832471
rs9499406 LINC02571 5.99E-08
6.05E-08
6.51E-08
8.19E-08
Replication: N=133 GTP African American women
Uddin et al, 2010 N=100 DNHS cg17709873
cg25831111 Retinoid-related orphan receptor alpha (RORA)
 Coenzyme A synthase (COASY) 3.00E-3 (unadjusted)
 1.00E-3 (unadjusted)
Smith et al, 2011 N=110 African Americans cg24577137
 cg08081036
 cg20098659
 cg07967308
 cg07759587 Translocated promoter region, nuclear basket protein (TPR)
 Annexin A2 (ANXA2)
 C-type lectin domain family 9 member a (CLEC9A)
 Acid phosphatase 5, Tartrate resistant (ACP5)
 TLR8 toll like receptor 8 (TLR8) 1.90E-06
 9.30E-06
 4.30E-06
 8.00E-06
 1.10E-05
Uddin et al, 2013 N=100 DNHS 118 CpG sites/
 116 genes 1.00E-2 (unadjusted)
Mehta et al, 2013 N=168 GTP 458 CpG sites/
 164 genes <5.00E-2
Mehta et al, 2017 Discovery: 
N=211
 
 
 Replication: N=115 Australian male Vi-etnam war veterans
 
 GTP males cg26499155
cg02357741
 cg09325682
 cg17750109
 cg16277944 Intergenic (43 kb from leucine-rich repeat contain-ing 3B [LRRC3B])
 BR Serine/threonine kinase 1 (BRSK1)
 Lipocalin 8 (LCN8)
 Nerve growth factor (NGF)
 Dedicator of cytokinesis 2 (DOCK2) 7.94E-07
 2.24E-06
 3.28E-06
 3.06E-06
 4.95E-06
Rutten et al, 2017 Discovery: N=93
 
 
Replication: N=98 Male Dutch 
military veterans
 
 Male American mili-tary 
veterans 17 DMPs and 12 DMRs Dual specificity phosphatase 22 (DUSP22)
 Histone cluster 1 H2A pseudogene 2 (HIST1H2APS2)
 Hook microtubule tethering Protein 2 (HOOK2)
 Ninjurin 2 (NINJ2)
 Paired box 8 (PAX8)
 Ring finger protein 39 (RNF39)
 Zinc finger protein 57 (ZFP57) <5.00E-2