Table 1.

Members of the selectin and integrin group of CAMs and their ligands/counter-receptors expressed in the healthy and inflamed liver.

Adhesion Molecule	Adhesion Molecule Expressing Resident and Immigrated Liver Cell Type	ECM Ligand and Counter-Receptor	Counter-receptor Expressing Resident and Immigrated Liver Cell Type
Selectins E-selectin P-selectin L-selectin	vEC vEC, P T	PSGL-1 PSGL-1 MECA-79, MAdCAM-1	LC LC EC
Integrins α1β1 (VLA-1) α2β1 (VLA-2) α3β1 (VLA-3) α4β1 (VLA-4) α5β1 (VLA-5) α6β1 (VLA-6) α11β1 αLβ2 (LFA-1) αMβ2 (Mac-1) αXβ2 (p150,95) αDβ2 αVβ1 αVβ3 αVβ5 αVβ6 αVβ8 α4β7 αEβ7	sEC, vEC, H, HSC C, sEC, vEC, periportal H, HSC C, vEC, H sEC, LC C, sEC, vEC, H, HSC C, vEC, H HSC LC LC LC LC HSC EC, HSC EC, HSC C, H H, HSC T T, D	CL, LN CL, LN LN FN, JAM-B, MAdCAM-1, VCAM-1 FN LN CL ICAMs, JAM-A ICAM, JAM-C ICAM, JAM-C ICAM, VCAM FN, LAP-TGFβ FN, TN, VN, LAP-TGFβ, JAM-A, JAM-C VN, LAP-TGFβ FN, TN, LAP-TGFβ VN, LAP-TGFβ FN, MAdCAM-1, VCAM-1 E-cadherin	C, EC, H, HSC EC, EpC, HSC, LC EC, EpC, HSC EC, C, H, HSC EC, C, H, HSC EC, C, H, HSC EC C, H, HSC

Mentioned are those selectins and integrins which have been analyzed in connection with liver inflammation and fibrosis in rodents and men. Liver cells or liver-infiltrating leukocytes expressing these CAMs and the corresponding counter-receptors are listed. Cell types in bold show expression only under inflammatory conditions. Abbreviations: C, cholangiocyte; sEC, sinusoidal endothelial cell; CL, collagen; D, dendritic cell; vEC, vascular endothelial cell; EpC, epithelial cell; FN, fibronectin; H, hepatocyte; HSC, hepatic stellate cell; ICAM, intercellular adhesion molecule; JAM, junctional adhesion molecule; LAP, latency-associated peptide; LC, leukocyte; MAdCAM, mucosal addressin cell adhesion molecule; P, platelet; PECAM, platelet-endothelial cell adhesion molecule; PSGL-1, P-selectin glycoprotein ligand-1; T, T cell; TGFβ, transforming growth factor beta; TN, tenascin-C; VCAM, vascular cell adhesion molecule; VN, vitronectin.