Table 1.
Top enriched pathway/gene clusters for group1/2 genes identified from t-SNE.
| Pathway | Count in Gene Set | FDR |
|---|---|---|
| Biological Process (GO) | ||
| small molecule metabolic process (GO:0044281) | 102/933 | 1.94 × 10−83 |
| oxidation-reduction process (GO:0055114) | 82/564 | 1.06 × 10−73 |
| generation of precursor metabolites and energy (GO:0006091) | 50/187 | 4.30 ×10−54 |
| Molecular Function (GO) | ||
| catalytic activity (GO:0003824) | 118/2668 | 3.23 × 10−58 |
| oxidoreductase activity (GO:0016491) | 61/458 | 3.20 × 10−51 |
| cofactor binding (GO:0048037) | 46/350 | 1.55 × 10−37 |
| Cellular Component (GO) | ||
| mitochondrion (GO:0005739) | 123/817 | 3.99 × 10−122 |
| mitochondrial part (GO:0044429) | 94/514 | 1.14 × 10−95 |
| mitochondrial matrix (GO:0005759) | 52/179 | 7.22 × 10−59 |
| KEGG Pathway | ||
| metabolic pathways (rno01100) | 109/1240 | 3.34 × 10−82 |
| oxidative phosphorylation (rno00190) | 40/130 | 1.52 × 10−45 |
| carbon metabolism (rno01200) | 37/112 | 4.08 × 10−43 |
| Reactome Pathway | ||
| TCA cycle and respiratory electron transport (RNO-1428517) | 46/123 | 8.62 × 10−56 |
| metabolism (RNO-1430728) | 82/1330 | 2.63 × 10−47 |
| pyruvate metabolism and TCA cycle (RNO-71406) | 22/34 | 2.13 × 10−30 |