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. 2019 Nov 30;8(12):1551. doi: 10.3390/cells8121551

Figure 4.

Figure 4

Expression of AT1 and AT2 receptors in the adult ventricular–subventricular zone (V-SVZ) and neurospheres generated from the V-SVZ of mice. (A) AT1 receptor expression was higher in the microdissected V-SVZ of AT2 receptor deficient (AT2-KO) mice and AT2 receptor expression was lower in the microdissected V-SVZ of AT1 receptor deficient (AT1-KO) mice and wild-type (WT) mice treated with the AT1 antagonist candesartan. (B) AT1 expression was higher in neurospheres treated with the AT2 antagonist PD123319 than in controls, and AT2 expression was lower in neurospheres treated with the AT1 antagonist candesartan than in controls. The number of primary neurospheres obtained from WT, AT1-KO, and AT2-KO mice is shown in (C). (D) Bar graphs showing the number of neurospheres derived from AT1-KO or AT2-KO mice after the corresponding treatments. All culture data were obtained from at least three separate experiments. Data are means ± SEM. * p < 0.05 relative to controls (Student’s t-test or one-way ANOVA and Bonferroni post hoc test). Ang II = angiotensin II; CGP42112A = AT2 receptor agonist; ZD7155 = AT1 receptor antagonist.