Table 1.

VALDIG criteria for the diagnosis of portal sinsusoidal vascular disease.

Clinical Signs of Portal Hypertension (Any One of the Following †) • Splenomegaly or hypersplenism • Esophageal varices • Ascites (non-malignant) • Minimally increased hepatic venous pressure gradient • Portovenous collaterals

Exclusion of Cirrhosis on Liver Biopsy

Exclusion of chronic liver disease causing cirrhosis or non-cirrhotic portal hypertension ‡ • Chronic viral hepatitis B or C • Non-alcoholic or alcoholic steatohepatitis • Autoimmune hepatitis • Hereditary hemochromatosis • Wilson’s disease • Primary biliary cholangitis

Exclusion of Conditions Causing Non-Cirrhotic Portal Hypertension • Congenital liver fibrosis • Sarcoidosis • Schistosomiasis

Patent Portal and Hepatic Veins (Doppler Ultrasound or CT Scanning)

All criteria must be fulfilled to diagnose portal sinusoidal vascular disease † Splenomegaly must be accompanied by additional signs of portal hypertension to fulfil this criterion. ‡ Chronic liver disease must be excluded, because severe fibrosis might be understaged on liver biopsy Addapted from De Gottardi et al. [5].