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Iron metabolism at the cellular level and its regulation. TfR: Transferrin receptor; IRE: Iron-responsive element; RME: Receptor-mediated endocytosis; E: Endosome; ISCM: Iron–sulphur cluster machinery; Ff: Transferrin; IRP: Iron-responsive protein; FeS: Iron–sulphur cluster; XS: Unknown sulphur transporter; CIAM: Cytosolic iron–sulphur cluster assembly machinery; PCBP: Poly (rC) binding protein.
