Table 3.
Predicted functional effects of KRAS G12S, A59T, and Y137C, and NRAS A11V.
| Protein | Mutation | Classification | Polyphen-2 (score) | SIFT (score) | Align GVGD (GD Score) |
|---|---|---|---|---|---|
| KRAS | G12D | canonical | Possibly damaging (0.517) | Damaging (0.00) | Class C65 (93.77) |
| KRAS | G12S | COSMIC | Possibly damaging (0.682) | Damaging (0.01) | Class C55 (55.27) |
| KRAS | A59T | COSMIC | Possibly damaging (0.936) | Damaging (0.03) | Class C55 (58.02) |
| KRAS | Y137C | novel | Benign (0.353) | Damaging (0.00) | Class C65 (193.72) |
| NRAS | G12D | canonical | Possibly damaging (0.488) | Damaging (0.00) | Class C65 (93.77) |
| NRAS | A11V | novel | Possibly damaging (0.922) | Damaging (0.02) | Class C55 (64.43) |