Table 2.

Effects of POPDC proteins on cell proliferation and cell death.

Cell Type	Effects of POPDC Protein on Proliferation	Potential/Suggested Mechanism	Ref.
Colorectal carcinoma cells	Forced expression of POPDC1 reduces cell proliferation	Unknown	[39]
Corneal epithelial cells	POPDC1 affects signaling pathways relevant to cell proliferation	Regulation of RhoA and Wnt signaling	[39]
Epithelial breast cancer cells	Suppression of POPDC1 enhances and forced expression reduces cell proliferation	Not suggested	[37]
Epithelial breast cancer cells	Forced expression of POPDC1 inhibits EGF-mediated cell proliferation	EGF suppresses POPDC1 expression	[43]
Colitis-associated cancer cells	POPDC1 null mutant mice display increased tumor multiplicity	Increased c-Myc levels via POPDC1- PR61α interaction	[10]
Cardiac myocytes	Serum starvation enhances POPDC1 which is protective against apoptosis	Regulation of Rac1 and Bnip3	[53]
Uveal melanoma cells	Forced expression of POPDC1 inhibits cell proliferation	Regulation of ZO-1 and ZONAB	[42]
Mouse embryonic fibroblasts	POPDC1 regulates the activity of pathways relevant to cell proliferation	Interaction with GEFT Regulation of Rac1 and Cdc42	[54]