Table 3.
Primary differentially expressed miRNAs that can play a central role in female reproductive physiology and embryology.
| miRNA Name | miRBase Accession Number | Tissue/Cell Expressed | DE-miRNA Condition(s) | Main Publication(s) |
|---|---|---|---|---|
| hsa-miR-9 | MIMAT0000441 | 1. Granulosa cells 2. Follicular fluid |
1. PCOS vs. oocyte donors 2. PCOS vs. oocyte donors |
[17,30] |
| hsa-miR-21 | MIMAT0000076 | 1. Granulosa cells 2. Cumulus cells 3. Follicular fluid |
1. PCOS vs. oocyte donors 2. Poor-responders vs. non-poor responders 3. Older vs. younger women |
[26,29,30] |
| hsa-miR-27b | MIMAT0000419 | 1. Follicular fluid 2. Cumulus cells 3. Blastocysts |
1. MII vs. GV 2. Poor-responders vs. non-poor responders 3. Aneuploid vs. euploid |
[29,32,38] |
| hsa-miR-29b | MIMAT0000100 | Follicular fluid | MII vs. GV and MII vs. MI | [32] |
| hsa-miR-30a | MIMAT0000087 | 1. Follicular fluid 2. Embryonic tissue |
1. PCOS vs. oocyte donors 2. EP vs. VTOP |
[18,36] |
| hsa-miR-146a | MIMAT0000449 | Granulosa cells | PCOS vs. oocyte donors and Poor ovarian response vs. oocyte donors | [30] |
| hsa-miR-150 | MIMAT0000451 | 1. Follicular fluid 2. Cumulus cells |
1. Non-viable vs. viable blastocysts 2. Poor-responders vs. non-poor responders |
[28,29] |
| hsa-miR-339-3p | MIMAT0004702 | 1. Follicular fluid 2. Blastocysts |
1. MII vs. GV 2. Aneuploid vs. euploid |
[32,38] |
| hsa-miR-424 | MIMAT0001341 | 1. Follicular fluid 2. Cumulus cells 3. Follicular fluid |
1. Non-viable vs. viable blastocysts 2. Poor-responders vs. non-poor responders 3. Older vs. younger women |
[28,29,32] |
| hsa-miR-451 | MIMAT0001631 | 1. Follicular fluid 2. Embryonic tissue |
1. MII vs. GV and MII vs. MI 2. EP vs. VTOP |
[32,36] |
| hsa-miR-663b | MIMAT0005867 | 1. Follicular fluid 2. Cumulus cells |
1. Non-viable vs. viable blastocysts 2. Poor-responders vs. non-poor responders |
[28,29] |
| hsa-miR-1275 | MIMAT0005929 | 1. Cumulus cells 2. Granulosa cells |
1. DOR vs. NOR 2. PCOS vs. oocyte donors |
[21,25] |
Abbreviations: DOR, diminished ovarian reserve; EP, ectopic pregnancies; GV, germinal vesicle; MI, metaphase I; MII, metaphase II; NOR, normal ovarian reserve; PCOS, polycystic ovary syndrome; VTOP, voluntary termination of pregnancy.