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. 2019 Dec 17;8(12):1658. doi: 10.3390/cells8121658

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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CD47 modulates the expression and subcellular localization of mesenchymal and epithelial factors in OSCC. (A,B) Immunofluorescent staining images, showing the expression of CD47, vimentin, and E-cadherin in SAS WT, and shCD47-1 or shCD47-2 cells. Representative dot plot of the correlative expression of (C) CD47 mRNA versus vimentin mRNA or (D) CD47 mRNA versus CDH1 mRNA in OSCC patients from the Roepman cohort, n = 220 using the R2 online genomic analysis and visualization software. (E) The associative network of the interaction between CD47 and molecular moieties involved in stem cell development, stem cell differentiation, stem cell maintenance, positive regulation of cell migration, and positive regulation of cell motility. Sp, orosphere; DAPI, nuclear staining.