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The role of mTOR in glucose metabolism. mTORC1 controls glycolysis via HIF1α and MYC. Through these transcription factors, it promotes the expression of genes whose products are involved in glucose metabolism including glucose transporters and glycolytic enzymes. mTORC2 also has a positive role in the regulation of glucose metabolism. The mTORC2 target, Akt, modulates glucose transport and phosphorylates glycolytic enzymes.
