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. 2019 Nov 25;8(12):1511. doi: 10.3390/cells8121511

Figure 2.

Figure 2

Schematic representation of the main pathways and down-stream effectors involved in cAMP signalling in HCC. GPCR, protein G coupled receptor; VPAC, vasoactive intestinal polypeptide receptor 1 or VIPR1; RA, retinoic acid; CREB, cAMP response element-binding protein; cdk2, cyclin-dependent kinase 2; GSK-3β glycogen synthase kinase 3β; ERK, extracellular-signal-regulated kinase.